Publications

@article{gu2026thz, title={Data-efficient self-supervised 3DCNN for real-time terahertz image denoising and enhancement}, author={Li, Xinhua and Li, Xiaoran and Gu, Yuanjie and Qian, Xinyan and Sun, Jiandong and Dong, Biqin and Zheng, Xiaoping}, journal={Optics and Laser Technology}, volume={196}, pages={114656}, year={2026}}

@article{gu2025enhancing, title={Enhancing Biomedical Optical Volumetric Imaging via Self-Supervised Orthogonal Learning}, author={Gu, Yuanjie and Wang, Yiqun and Xuan, Ang and Wang, Jianping and Wang, Linyi and Zhang, Lei and Li, Xiaoran and Wu, Yao and Zhang, Jun and Lu, Zhi and Dong, Biqin}, journal={Science Advances}, year={2025}}

@article{wang2025realtime, title={Real-time Self-supervised Denoising for High-speed Fluorescence Neural Imaging}, author={Wang, Yiqun and Gu, Yuanjie and Wang, Jianping and Xuan, Ang and Kong, Cihang and Fang, Wei-Qun and Li, Dongyu and Zhu, Dan and Ding, Fengfei and Dong, Biqin}, journal={Nature Communications}, volume={16}, pages={9396}, year={2025}}

@article{gu2025gama, title={GaMA: Stochastic Gaussian-masked Denoiser for Enhanced Fluorescence Microscopy of Subcellular Structures and Neural Dynamics}, author={Gu, Yuanjie and Wang, Yiqun and Zhao, Zhenyao and Lu, Jun and Xu, Lei and Lu, Zhi and Dong, Biqin}, journal={Advanced Technology in Neuroscience}, volume={3}, pages={1-5}, year={2025}}

@article{gu2025automated, title={Automated Enhanced Handheld Fundus Photography via Unpaired Learning}, author={Gu, Yuanjie and Yang, Jiacheng and Wang, Yiqun and Ye, Mengwen and Li, Xin and Li, Xiaoran and Li, Na and Zhang, Jun and Zhao, Yitian and Yu, Zekuan and Dong, Biqin}, journal={IEEE Transactions on Instrumentation and Measurement}, volume={74}, pages={1-12}, year={2025}}

@article{zhang2025automated, title={Automated Diagnosis of Non-Melanoma Skin Cancer: A Joint Learning Approach Using Optical Attenuation Coefficients}, author={Zhang, Lei and Li, Xiaoran and Chen, Wen and Gu, Yuanjie and Wu, Hao and Lu, Zhong and Dong, Biqin}, journal={npj Digital Medicine}, volume={8}, pages={232}, year={2025}}

@article{yang2025fedgfm, title={Fed-GFM-DG: A Privacy-Preserving Framework for Fundus Image Segmentation via Generative-based Feature Generalization and Mask-Guided Aggregation}, author={Yang, Jiacheng and Gu, Yuanjie and Gao, Shujian and Ren, Wei and Yu, Zekuan}, journal={Biomedical Signal Processing and Control}, volume={106}, pages={1-14}, year={2025}}

@article{xu2024deeplearning, title={Deep-learning-assisted spectroscopic single-molecule localization microscopy based on spectrum-to-spectrum denoising}, author={Xu, Dandan and Gu, Yuanjie and Lu, Jun and Xu, Lei and Wang, Wei and Dong, Biqin}, journal={Nanoscale}, volume={16}, number={11}, pages={5729-5736}, year={2024}}

@article{cai2024super, title={Super Resolution Reconstruction of Fluorescence Microscopy Image by Convolutional Network with Physical Priors}, author={Cai, Qiangyu and Lu, Jun and Gu, Wenting and Xiao, Di and Li, Boyi and Xu, Lei and Gu, Yuanjie and Dong, Biqin and Liu, Xin}, journal={Biomedical Optics Express}, volume={15}, number={11}, pages={6638-6653}, year={2024}}

@article{gu2023segcofusion, title={SegCoFusion: An Integrative Multimodal Volumetric Segmentation Cooperating with Fusion Pipeline to Enhance Lesion Awareness}, author={Gu, Yuanjie and Guan, Yinghan and Yu, Zekuan and Dong, Biqin}, journal={IEEE Journal of Biomedical and Health Informatics}, volume={27}, number={12}, pages={5860-5871}, year={2023}}

@article{gu2023physics, title={Physics Driven Deep Retinex Fusion for Adaptive Infrared and Visible Image Fusion}, author={Gu, Yuanjie and Xiao, Zhibo and Guan, Yinghan and Dai, Haoran and Liu, Cheng and Xue, Liang and Wang, Shouyu}, journal={Optical Engineering}, volume={62}, number={8}, pages={083101}, year={2023}}

@article{xiao2023deep, title={Deep SBP+: Breaking Through the Space-bandwidth Product Limit based on a Physical-driven Cycle Constraint Framework}, author={Xiao, Zhibo and Gu, Yuanjie and Zhu, Lin and Liu, Cheng and Wang, Shouyu}, journal={Journal of the Optical Society of America A}, volume={40}, number={5}, pages={833-840}, year={2023}}

@article{xiao2023deepgamma, title={Deep-Gamma: Deep Low-excitation Fluorescence Imaging Global Enhancement}, author={Xiao, Zhibo and Guan, Yinghan and Hou, Wei and Gu, Yuanjie and Wang, Shouyu}, journal={Optics Letters}, volume={48}, number={9}, pages={2496-2499}, year={2023}}

@article{gu2022deep, title={Deep Low-excitation Fluorescence Imaging Enhancement}, author={Gu, Yuanjie and Xiao, Zhibo and Hou, Wei and Liu, Cheng and Jin, Ying and Wang, Shouyu}, journal={Optics Letters}, volume={47}, number={16}, pages={4175-4178}, year={2022}}

@article{gu2022deepfusion, title={Deep Fusion Prior for Plenoptic Super-resolution All-in-focus Imaging}, author={Gu, Yuanjie and Guan, Yinghan and Xiao, Zhibo and Dai, Haoran and Liu, Cheng and Wang, Shouyu}, journal={Optical Engineering}, volume={61}, number={12}, pages={123103}, year={2022}}

@article{gu2022openrefocus, title={OpenRefocus: An Open-source Qt-based Tool for Light Field Parallel Refocusing}, author={Gu, Yuanjie and Yu, Miao and Ai, Lingyu and Jiang, Zhilong and He, Xiaoliang and Kong, Yan and Wang, Shouyu}, journal={Optical Engineering}, volume={61}, number={6}, pages={063108}, year={2022}}

@article{chen2022automatic, title={Automatic Whole Blood Cell Analysis from Blood Smear using Label-free Multi-modal Imaging with Deep Neural Networks}, author={Chen, Chao and Gu, Yuanjie and Xiao, Zhibo and Wang, Hailun and He, Xiaoliang and Jiang, Zhilong and Kong, Yan and Liu, Cheng and Xue, Liang and Vargas, Javier and Wang, Shouyu}, journal={Analytica Chimica Acta}, volume={1229}, pages={340401}, year={2022}}

@article{yu2021repaid, title={REPAID: Resolution-enhanced Plenoptic All-in-focus Imaging using Deep Neural Networks}, author={Yu, Miao and Gu, Yuanjie and Jiang, Zhilong and He, Xiaoliang and Kong, Yan and Liu, Cheng and Wang, Shouyu}, journal={Optics Letters}, volume={46}, number={12}, pages={2896-2899}, year={2021}}